HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 *10-3 µM and 5 µM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKalpha1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver[1].
Molecular Weight:
425.56
Purity:
99.52
CAS Number:
[2919766-97-3]
Formula:
C25H35N3O3
Target:
AMPK,HDAC
Application Notes:
MCE Product type: Reference compound
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