ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 µM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia[1].
Molecular Weight:
231.25
Purity:
99.65
CAS Number:
[140481-05-6]
Formula:
C13H13NO3
Target:
Anaplastic lymphoma kinase (ALK),Caspase
Application Notes:
MCE Product type: Reference compound
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