GSK3beta-IN-2 (Compound S01) is the inhibitor for GSK3beta with an IC50 of 0.35 nM. GSK3beta-IN-2 activates Wnt/beta-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3beta-IN-2 inhibits Abeta-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3beta-IN-2 ameliorates Alzheimers Disease in zebrafish model[1].
Molecular Weight:
390.44
Purity:
98.75
CAS Number:
[3068378-38-8]
Formula:
C25H18N4O
Target:
GSK-3,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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