THX6 is an hClpP activator with an EC50 of 1.18 µM. THX6 improves off-target profile with no affinity for hD2R and only weak affinity for hD3R (Ki = 51.1 µM) in HEK293 cells. THX6 shows good cytotoxicity in ONC201-resistant cells with an IC50 of 0.13 µM. THX6 changes the levels of fatty acids (PUFAs, MUFAs, and SFAs) in DIPG cells. THX6 decreases the level of proteins involved in oxidative phosphorylation, biogenesis, and mitophagy proteins, thereby resulting in a global collapse of mitochondrial integrity and function. THX6 can be used for diffuse intrinsic pontine glioma research[1].
Molecular Weight:
441.31
Purity:
99.97
CAS Number:
[3076954-42-9]
Formula:
C22H18Cl2N4O2
Target:
ClpP
Application Notes:
MCE Product type: Reference compound
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