S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 µM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD(P)H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury[1][2].
Molecular Weight:
544.79
CAS Number:
[148089-70-7]
Formula:
C31H48N2O4S
Target:
Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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