NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection[1].
Molecular Weight:
478.54
CAS Number:
[1227303-03-8]
Formula:
C25H30N6O4
Target:
Bacterial,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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