Tosposertib is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM). Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFbeta and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer[1].
Molecular Weight:
317.35
Purity:
99.89
CAS Number:
[1418305-55-1]
Formula:
C17H15N7
Target:
Anaplastic lymphoma kinase (ALK),VEGFR
Application Notes:
MCE Product type: Reference compound
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