3,5-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG). 3,5-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3,5-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3,5-DiOA-dC also increases the levels of TNF-alpha and IFN-gamma in murine melanoma model[1].
Molecular Weight:
756.11
Formula:
C45H77N3O6
Target:
STING
Application Notes:
Reference compound
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