SL-176 is a PPM1D (Wip1) inhibitor. SL-176 inhibits lipid droplet formation, downregulates the mRNA and protein expression of PPARgamma and C/EBPalpha, and blocks adipocyte differentiation. SL-176 induces G2/M cell cycle arrest, apoptosis and inhibits cell proliferation in breast cancer cells overexpressing PPM1D, and activates components of the p53 pathway. SL-176 suppresses tumor growth in a zebrafish model of neuroblastoma. SL-176 is applicable to research related to obesity, breast cancer and neuroblastoma[1][2][3].
Molecular Weight:
456.81
Purity:
99.91
CAS Number:
[1809556-48-6]
Formula:
C24H48O4Si2
Target:
Apoptosis,Caspase,MDM-2/p53,Phosphatase
Application Notes:
MCE Product type: Reference compound
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