SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control[1].
Molecular Weight:
486.14
CAS Number:
[3052432-15-9]
Formula:
C19H15BrCl2N2O4
Target:
Fungal,MMP,Reactive Oxygen Species (ROS),Succinate Dehydrogenase
Application Notes:
MCE Product type: Reference compound
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