HNW005 is a dual inhibitor of NLRP3 inflammasome and urate transporter 1 (URAT1). It has a KD value of 204.6 nM and an IC50 of 1.7 µM for inhibiting NLRP3 inflammasome activation, and an IC50 of 6.4 µM for inhibiting uric acid transmembrane transport. When administered at a dose of 2 mg/kg in vivo, HNW005 can achieve a uric acid reduction rate of 64.8%. It can exert anti - inflammatory, analgesic, and uric acid - lowering activities by inhibiting the activation of NLRP3 inflammasome and uric acid transmembrane transport. HNW005 can be used in the research of gouty arthritis[1].
Molecular Weight:
375.30
Formula:
C18H12F3N3O3
Target:
NOD-like Receptor (NLR),URAT1
Application Notes:
MCE Product type: Reference compound
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