PSB-24000 (Compound 27) is a selective ecto-5-nucleotidase (CD73) inhibitor with a Ki value of 563 nM against human CD73 (Ki= 481 nM at membrane-bound CD73 in triple-negative breast cancer cells). PSB-24000 interferes with CD73s recognition and action on the substrate AMP, and prevents the generation of immunosuppressive and cancer-promoting adenosine from AMP. PSB-24000 is promising for research of cancers[1].
Molecular Weight:
531.87
Formula:
C20H28ClN5O6P2
Target:
CD73
Application Notes:
MCE Product type: Reference compound
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