Vancomycin prodrug (compound 13c) is a Vancomycin (HY-B0671) prodrug. Vancomycin prodrug shows antibacterial effect with MICs of 0.78 µM, 0.78 µM, 1.56 µM for S. aureus 330041, MRSA USA 300 and MRSA 3390, respectively. Vancomycin prodrug has the ability to quickly bind to Cys-34 residue of plasma. Vancomycin prodrug exhibits a good therapeutic effect on MRSA USA300 infected mice similar to Vancomycin. Vancomycin prodrug, an albumin-binding acid-sensitive prodrug, effectively reduces Vancomycins nephrotoxicity while maintaining its efficacy for Gram-positive bacterial infections[1].
Molecular Weight:
1805.63
Formula:
C85H95Cl2N11O29
Target:
Antibiotic,Autophagy,Bacterial
Application Notes:
MCE Product type: Reference compound
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