PDE4B-IN-4 (Compound 11E) is a PDE4B (IC50: 2.82 nM) and TNF-alpha (IC50: 7.20 nM) inhibitor. PDE4B-IN-4 inhibits neutrophilia in a mouse lipopolysaccharide (LPS)-induced sepsis model and exhibits anti-inflammatory activity[1].
Molecular Weight:
489.52
Formula:
C26H27N5O5
Target:
Phosphodiesterase (PDE),TNF Receptor
Application Notes:
MCE Product type: Reference compound
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