TDO-IN-2 (Compound 5c) is an orally active TDO inhibitor (IC50: 1.25 µM). TDO-IN-2 has antitumor activity in the Hepa1-6 hepatocellular carcinoma allograft mouse model. TDO-IN-2 has synergistic effects with the PD-1/PD-L1 inhibitor BMS-202 (HY-19745) and can be used to study tumor immune tolerance[1].
Molecular Weight:
345.35
Formula:
C20H15N3O3
Target:
Indoleamine 2,3-Dioxygenase (IDO)
Application Notes:
MCE Product type: Reference compound
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