VEN-02XX is an orally active and brain-permeable NLRP3 inhibitor. VEN-02XX inhibits the release of IL-1beta and IL-18 (IC50 0.3 and 0.28 µM, respectively). VEN-02XX restores memory and cognition, inhibits microgliosis, and reduces neuroinflammation and tau pathology in the 5XFAD/Rubicon KO mouse model. VEN-02XX may be used in the study of Alzheimers disease (AD)[1].
Molecular Weight:
396.79
Purity:
99.66
Formula:
C18H16ClF3N4O
Target:
NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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