FGA139 is a cysteine proteases inhibitor with IC50 values of 4.98/3.14 µM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFalpha) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research[1].
Molecular Weight:
861.83
Formula:
C48H58BF2N7O5
Target:
Cathepsin,NO Synthase,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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