SLW131 (Compound 10) is the antagonist for CCR7 with a good affinity of Ki of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 µM, inhibits beta-arrestin2 recruitment with an IC50 of 6.0 µM. SLW131 inhibits CCL19-induced cell morphological changes in primary BMDCs, and CCR7-mediated migration in mouse CD4+ T cell[1].
Molecular Weight:
461.53
CAS Number:
[681511-84-2]
Formula:
C21H27N5O5S
Target:
CXCR
Application Notes:
MCE Product type: Reference compound
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