DS-103 is an inhibitor for HDAC that inhibits HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8 with IC50s of 0.029, 0.123, 0.022, 0.367 and 9.26 µM, respectively. DS-103 inhibits Plasmodium falciparum 3D7 with IC50 of 5.08 µM. DS-103 exhibits cytotoxicity in cells A2780 and Cal27 with IC50 of 1.48 µM and 1.47 µM, reverses Cisplatin (HY-17394) resistance in A2780 and Cal27 with IC50 of 4.62 µM and 2.23 µM. DS-103 exhibits synergistic effect with Cisplatin (HY-17394), enhances Cisplatin-induced apoptosis[1].
Molecular Weight:
487.59
Formula:
C28H33N5O3
Target:
HDAC,Parasite
Application Notes:
MCE Product type: Reference compound
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