Anticancer agent 267 (Compound 5q) is the activator for RIPK3 and MLKL. Anticancer agent 267 inhibits the proliferation in a variety of cancer cell lines (IC50 for MDA-MB-231, MDA-MB-486 and MCF-7 is 9.79, 10.77 and 5.94 µM, respectively), arrests cell cycle at subG1 phase, and induces necroptosis in cell MDA-MB-231. Anticancer agent 267 exhibits antitumor activity in mouse xenograft models[1].
Molecular Weight:
333.32
Formula:
C13H11N5O4S
Target:
Mixed Lineage Kinase,Necroptosis,RIP kinase
Application Notes:
MCE Product type: Reference compound
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