UNC10013 is an inhibitor targeting the triple Tudor domain (3TD) of SETDB1. UNC10013 covalently binds to Cys385 of SETDB1 3TD, acts as a negative allosteric modulator of the methyltransferase domain of SETDB1, reduces the level of Akt methylation mediated by SETDB1, and blocks Tyr308 phosphorylation of Akt. UNC10013 is applicable to cancer-related research[1].
Molecular Weight:
982.85
Purity:
99.90
Formula:
C37H54F12N8O9
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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