AUR1545 is a selective KAT2A/KAT2B ((GCN5/PCAF)) PROTAC degrader that induces monocyte differentiation and inhibits the growth of acute myeloid leukemia cells. AUR1545 inhibits cell growth, induces epithelial differentiation and suppresses tumor growth in small cell lung cancer models. AUR1545 inhibits cell growth and induces differentiation in neuroendocrine prostate cancer cells and primary patient-derived organoids. AUR1545 is applicable to research related to acute myeloid leukemia, small cell lung cancer and neuroendocrine prostate cancer[1].
Molecular Weight:
828.80
Purity:
99.58
CAS Number:
[3031593-79-7]
Formula:
C41H50BrN9O5
Target:
Histone Acetyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound
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