MJ210 is a modulator of the NF-kappaB and MAPK pathways with oral activity and the ability to penetrate the blood-brain barrier, and it exhibits neuroprotective activity. In vitro, 5 µM of MJ210 can increase the survival rate of SH-SY5Y cells treated with Rotenone (HY-B1756) to 81.9% and reduce the level of ROS, etc. In vivo, 5 mg/kg of MJ210 can improve the motor impairment in a rat model of Parkinsons disease. MJ210 can be used in the research of neurological diseases, such as Parkinsons disease[1].
Molecular Weight:
398.45
Formula:
C22H26N2O5
Target:
NF-kappaB,p38 MAPK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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