GI-Y2 is an orally active, selective Gasdermin D (GSDMD) inhibitor (Kd = 36.0 µM) with anti-pyroptosis activity. GI-Y2 targets GSDMD, impairs membrane anchoring of GSDMD-NT, and blocks GSDMD-dependent lipid binding and pore formation. GI-Y2 suppresses GSDMD-dependent pyroptosis and inflammation, mitigates atherosclerosis and cardiac injury, boosts cell survival, and reduces IL-1beta/IL-18 secretion. GI-Y2 can be used for the research of atherosclerosis and septic myocardial injury[1][2].
Molecular Weight:
386.38
CAS Number:
[1008710-58-4]
Formula:
C18H14N2O6S
Target:
Interleukin Related,Pyroptosis
Application Notes:
MCE Product type: Reference compound
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