GI-Y2 is an inhibitor of GSDMD and can inhibit Pyroptosis of macrophages induced by oxidized low-density lipoprotein (ox-LDL). In vivo, GI-Y2 can dose-dependently reduce atherosclerotic plaques in ApoE-/- mice and decrease the lesion size and fibrosis degree of the aortic root. GI-Y2 is expected to be used in the research of pyroptosis and cardiovascular diseases, such as atherosclerosis[1].
Molecular Weight:
386.38
CAS Number:
[1008710-58-4]
Formula:
C18H14N2O6S
Target:
Pyroptosis
Application Notes:
MCE Product type: Reference compound
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