Hyp-dBET1 is a PROTAC degrader targeting BRD4. Hyp-dBET1 has an IC50 value of 3.4 µM in MDA-MB-231 cells. Hyp-dBET1 can be activated by hypoxia and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study[1].
Molecular Weight:
920.39
Formula:
C45H42ClN9O9S
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound
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