PDGFRalpha kinase inhibitor 3 (Compound L7) is a highly potent inhibitor targeting the PDGFRalphaD842V kinase with IC50s values of 23.8 nM and 2.1 nM in biochemical and cellular assays, respectively. PDGFRalpha kinase inhibitor 3 binds to the ATP-binding pocket of PDGFRalphaD842V to block its downstream signaling pathways and inhibit kinase activity. PDGFRalpha kinase inhibitor 3 can be used for gastrointestinal stromal tumors (GISTs) study[1].
Molecular Weight:
385.46
Formula:
C23H23N5O
Target:
PDGFR
Application Notes:
MCE Product type: Reference compound
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