Ran-IN-1 (Compound M36) is an orally active and selective Ran GTPase inhibitor. Ran-IN-1 binds to the GDP-bound form of Ran (RanGDP) at the allosteric switch II pocket with high specificity, stabilizing the inactive state and reducing the active Ran-GTP population. Ran-IN-1 induces apoptosis and represses DNA repair pathways like HR and NHEJ in epithelial ovarian cancer (EOC) cells. Ran-IN-1 is promising for research of EOC, particularly high-grade serous carcinoma[1].
Molecular Weight:
517.56
CAS Number:
[2301869-11-2]
Formula:
C27H26F3NO4S
Target:
Apoptosis,Arf Family GTPase
Application Notes:
MCE Product type: Reference compound1
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