TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-alpha-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359), Black: Linker (HY-W007732B), Blue: E3 ligase ligand (HY-14658), E3 ligase ligand + Linker (HY-173358))[1].
Molecular Weight:
841.85
Purity:
99.54
Formula:
C43H40FN11O7
Target:
JAK,PROTACs,STAT
Application Notes:
MCE Product type: Reference compound1
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