VU0467319 (Compound VU319) is a highly selective and blood-brain-permeable, orally active M1 positive allosteric modulator (PAM) (EC50: 492 nM). VU0467319 is selective (EC50 > 30 µM) versus M2-5 for both human and rat. VU0467319 improves cognitive impairment in Alzheimers disease (AD) through central M1 muscarinic receptors. VU0467319 does not induce cholinergic adverse reactions and has potential in AD research[1].
Molecular Weight:
390.39
Purity:
98.53
CAS Number:
[1432438-14-6]
Formula:
C22H16F2N4O
Target:
mAChR
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
