NMDAR antagonist 5, CAS [[3038464-68-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-173398
Supplier Catalog Number:
HY-173398
Alternative Catalog Number:
MCE-HY-173398-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERT,DAT and NET). NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 µM) and monoamine transporter activities (SERT IC50 = 1.1 µM,DAT IC50 = 0.7 µM,NET IC50 = 2.7 µM). NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 µM), cardiotoxicity (IC50 = 24.5 µM)). NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression[1].
