TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC50: 10.2 µM). TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells[1].
Molecular Weight:
381.21
CAS Number:
[2857180-28-8]
Formula:
C16H16INO2
Target:
Apoptosis,Reactive Oxygen Species (ROS),TrxR
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
