VVD-699 is a covalent RAS-PI3K inhibitor. VVD-699 covalently binds to cysteine 242 in the RAS binding domain of PI3K p110alpha, thereby blocking the ability of RAS to activate PI3K activity. VVD-699 is able to inhibit the growth of RAS-mutated and HER2-overexpressing tumors. VVD-699 can be used to study cancers associated with RAS mutations (e.g., H358 lung cancer cells, A549 cells, FaDu cells)[1].
Molecular Weight:
573.10
Purity:
99.83
CAS Number:
[3055319-82-6]
Formula:
C25H30ClFN2O6S2
Target:
PI3K,Ras
Application Notes:
MCE Product type: Reference compound
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