Nur77 agonist-1, CAS [[2899254-71-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-173408
Supplier Catalog Number:
HY-173408
Alternative Catalog Number:
MCE-HY-173408-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 µM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 µM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research[1].
Molecular Weight:
443.89
CAS Number:
[2899254-71-6]
Formula:
C24H18ClN5O2
Target:
Ferroptosis,Glutathione Peroxidase,Nuclear Hormone Receptor 4A/NR4A,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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