PROTAC STING degrader-3 (Compound ST9) is a STING PROTAC degrader (DC50: 0.62 µM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-kappaB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI) (Pink: STING ligand (HY-47709), Blue: E3 ligase CRBN ligand (HY-41547), Black: linker)[1].
Molecular Weight:
752.73
Purity:
98.04
Formula:
C37H36N8O10
Target:
NF-kappaB,PROTACs,STING
Application Notes:
MCE Product type: Reference compound
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