HDAC11-IN-3, CAS [[2989934-63-4]] Preis auf Anfrage

Product Overview

• Article Name: HDAC11-IN-3, CAS [[2989934-63-4]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-173444
• Supplier Catalog Number: HY-173444
• Alternative Catalog Number: MCE-HY-173444-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 µM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research[1].

Product Properties

• Molecular Weight: 344.29
• CAS Number: [2989934-63-4]
• Formula: C18H11F3N2O2
• Target: Apoptosis,Ferroptosis,HDAC,Transferrin Receptor

Application Notes

• Application Notes: MCE Product type: Reference compound