8-BuS-AMP is a NTPDase1 inhibitor and a CD73/CD39 inhibitor, with an IC50 of 35 µM and a Ki value of 0.292 µM against human NTPDase1, its Ki values against human CD73 and CD39 are 1.19 µM and 0.847 µM, respectively. 8-BuS-AMP binds to the substrate-binding pockets of NTPDase1 and CD73 to effectively block the conversion of ATP and AMP to adenosine, thereby enhancing the activation and proliferation of human peripheral T lymphocytes. 8-BuS-AMP possesses excellent enzymatic hydrolysis resistance and metabolic stability, resists hydrolysis by multiple NTPDase subtypes, and shows no activity against P2Y1 and P2Y12 receptors. 8-BuS-AMP can be used in purinergic signaling pathway and cancer-related studies[1][2][3].
Molecular Weight:
435.39
Purity:
99.90
CAS Number:
[344402-39-7]
Formula:
C14H22N5O7PS
Target:
CD73,NTPDase
Application Notes:
MCE Product type: Reference compound1
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