TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM). TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and pi-pi stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNgamma to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research[1].
Molecular Weight:
519.55
CAS Number:
[3075572-35-6]
Formula:
C26H29N7O5
Target:
IKK
Application Notes:
MCE Product type: Reference compound1
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