MBL-IN-5 is a metallo-beta-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic[1].
Molecular Weight:
353.80
CAS Number:
[2876921-34-3]
Formula:
C20H16ClNO3
Target:
Bacterial,Beta-lactamase
Application Notes:
MCE Product type: Reference compound1
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