TFAP4/Wnt/beta-catenin-IN-1 (Compound A61) is an orally active TFAP4/Wnt/beta-catenin inhibitor. TFAP4/Wnt/beta-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC50: 3.92 µM). TFAP4/Wnt/beta-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/beta-catenin signaling pathway. TFAP4/Wnt/beta-catenin-IN-1 can be used in the study of gastric cancer[1].
Molecular Weight:
513.47
Formula:
C27H33BrN2O3
Target:
Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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