H052 is a selective Staphylococcus aureus alpha-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC50=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus[1].
Molecular Weight:
459.88
CAS Number:
[2886748-00-9]
Formula:
C21H15ClFN3O4S
Target:
Bacterial,Calcium Channel
Application Notes:
MCE Product type: Reference compound
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