MS115 is a selective PRMT5/MEP50 PROTAC degrader with DC50 values of 17.4 nM and 11.3 nM for PRMT5 and PRMT5 at 24 h in MDAMB468 cells, respectively. MS115 inhibits the proliferation of breast cancer cells((Pink: target protein ligand (HY-173562 ), Black: linker, Blue: VHL ligase (HY-47070))[1].
Molecular Weight:
1258.50
Formula:
C63H88FN11O13S
Target:
Histone Methyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound1
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