DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC50 = 0.16 µM) with low nanomolar EC50 values of 0.14 µM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis[1].
Molecular Weight:
434.58
CAS Number:
[2758171-54-7]
Formula:
C25H34N6O
Target:
Epigenetic Reader Domain,Necroptosis
Application Notes:
MCE Product type: Reference compound1
* VAT and and shipping costs not included. Errors and price changes excepted
