Nepafenac (AHR 9434, AL 6515), a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 µM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 µM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE2. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries[1][2][3].
Molecular Weight:
254.28
Purity:
99.56
CAS Number:
[78281-72-8]
Formula:
C15H14N2O2
Target:
COX,Endogenous Metabolite,Prostaglandin Receptor
Application Notes:
MCE Product type: Reference compound1
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