SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 µM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models[1].
Molecular Weight:
350.35
Purity:
99.40
CAS Number:
[433953-86-7]
Formula:
C19H15FN4O2
Target:
Autophagy,Sirtuin
Application Notes:
MCE Product type: Reference compound
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