TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, >1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].
Molecular Weight:
420.92
Formula:
C17H21ClN8OS
Target:
Apoptosis,SHP2
Application Notes:
MCE Product type: Reference compound
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