CC-647 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARalpha-ZBTB16 (with a DC50 of 103 nM). CC-647 is promising for research of ZBTB16-RARalpha-associated acute promyelocytic leukemia (APL)[1].
Molecular Weight:
406.43
Purity:
99.58
CAS Number:
[1061605-35-3]
Formula:
C23H22N2O5
Target:
E1/E2/E3 Enzyme,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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