(S)-dHTC1 is a molecular glue degrader targeting the transcriptional co-activator ENL. (S)-dHTC1 binds the ligase with high affinity only after forming the ENL:dHTC1 complex with an IC50 value of 93 nM. (S)-dHTC1 degrades ENL in MV4,11 cells with a DC50 value of 26 nM. (S)-dHTC1 can be used for acute myeloid leukemia study[1].
Molecular Weight:
676.79
CAS Number:
[3081383-46-9]
Formula:
C33H40N8O6S
Target:
PROTACs
Application Notes:
MCE Product type: Reference compound
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