AMG410, CAS [[3040175-17-2]]

Product Overview

• Article Name: AMG410, CAS [[3040175-17-2]]
• Biozol Catalog Number: MCE-HY-173632
• Supplier Catalog Number: HY-173632
• Alternative Catalog Number: MCE-HY-173632-100MG,MCE-HY-173632-1MG,MCE-HY-173632-5MG,MCE-HY-173632-25MG,MCE-HY-173632-50MG,MCE-HY-173632-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 shows greater than 100-fold selectivity against both HRAS and NRAS. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM, Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. AMG410 can be used for the study of colorectal, pancreatic, and lung cancers[1][2].

Product Properties

• Molecular Weight: 656.08
• Purity: 99.75
• CAS Number: [3040175-17-2]
• Formula: C31H32ClF2N7O5
• Target: Ras

Application Notes

• Application Notes: MCE Product type: Reference compound