Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].
Molecular Weight:
194.15
Purity:
99.98
CAS Number:
[85622-93-1]
Formula:
C6H6N6O2
Target:
Apoptosis,Autophagy,DNA Alkylator/Crosslinker
Application Notes:
MCE Product type: Reference compound
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