Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cant cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
Molecular Weight:
342.82
Purity:
99.98
CAS Number:
[34233-69-7]
Formula:
C18H19ClN4O
Target:
Dopamine Receptor,Drug Metabolite,mAChR
Application Notes:
MCE Product type: Reference compound
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